"The Vampire Murders"

 "Tonight the vampire may walk again, unless we prefer to think that the skeleton parades these premises. Whichever the case, we shall learn the facts - of murder!" - The  Shadow 

A dying sigh of wind circled Haldrew Hall, forbidding mansion of death, and echoed a whisper that gave a mirthfully, sibilant laugh. Could The Shadow keep his promise that he, strange master of darkness, would take a hand in solving the weird riddle of Haldrew Hall, after mere humans had finished their speculations on the subject of a roving vampire that had vanished without a rattle of its bones?  - The Shadow Wiki

Here's a bit of trivia, courtesy of The Shadow Wiki: 

The character Varney Haldrew is named after the original "Varney, the Vampire" who was featured in a Victorian era, Gothic-horror story, Varney the Vampire; or, the Feast of Blood by James Malcolm Rymer. "Varney" became a major influence on later vampire fiction, most notably the renowned novel Dracula (1897), by Bram Stoker. Many of today's basic concepts of a vampire, fangs, punctured necks and hypnotic powers, originated from the Varney pamphlets that were published from 1845 to 1847. The original "musty, leather covered book" is mentioned in The Shadow story.

A simplified version of this novel appeared as one of the tales in Shadow Comics less than a year later.